On the present review, we give an overview on artemisinin's antiviral activity. However, only limited research has been conducted on this species. Artemisia annua extracts show very little toxicity and artemisinin-based drugs are widely used to treat malaria even in newborns. Artemisia afra is one of the most popular and commonly used herbal medicines in southern Africa. Luteolin (3,4,5,7-tetrahydroxyflavone) is a widespread flavonoid aglycon structurally related to quercetin. A 2005 Chinese study showed that Artemisia annua had strong antiviral activity against SARS-CoV, the coronavirus responsible for the SARS epidemic in 2003. It helps zinc to exert its antiviral effect on COVID-19 and is a better alternative to hydroxychloroquine as an ionophore. We sought to study the ability of different A. annua and A. afra extracts and the Covid-Organics drink produced in Madagascar to inhibit SARS-CoV-2 and feline coronavirus (FCoV) replication in vitro. There is good in vitro and in vivo evidence for the activity of artemisinin and its derivatives against DNA viruses of the Herpesviridae and Hepadnaviridae families such as cytomegaloviruses, human herpesvirus 6, herpes simplex viruses 1 and 2, Epstein-Barr virus and Hepatitis B virus. Recently, research investigations are more focused to evaluate its antiviral potential against HIV, as it is a highly emerging disease throughout the world. Artemisia afra is the only species in this genus indigenous to the African continent. Wildeals (Artemisia afra) and wynruit (Ruta graveolens) are other medicinal plants that have been used by some indigenous people in South Africa to treat several conditions. 29. It helps to fight obesity, high blood pressure, and insulin resistance. Artemisia afra Jacq. Several extracts as well as Covid- According to a recent publication by Van Wyk (2008), only 42 scientific publications and 2 patents related to A. afra are available of which 27 publications and 1 patent were published between Similar extracts, in a cell culture antiviral assay, were found not to reduce the infectivity of either Coxsackie B2 virus or HSV-1. Laboratory studies this year indicated that the leaves of the plant also have strong antiviral activity against SARS-CoV-2, the virus that causes COVID-19. Threatening the pharmaceutical industry Artemisia afra and luteolin. These have mostly been used as mono therapies, but in the Northern Cape Province, Griqualand-West, South Africa, they are being used as combination therapies also. The effects of a range of common dietary flavonoids on the growth of Plasmodium falciparum has been studied by A antiviral activity of 16 South African plant species 12 showed that aqueous extracts of Artemisia afra were cytotoxic, at higher concentrations used in the assay, to HeLa, Vero, Jurkat E6.1, AA-2 and CEM-SS cells. The ethnobotanical use of this flavone includes applications in the treatment of cough, diarrhea, dysentery, diabetes, cancer and malaria. extracts of Artemisia annua and Artemisia afra have been widely used in Africa in efforts to prevent and fight COVID-19 infections. ex Willd. The plant is used in Chinese and Ayurvedic systems of medicine for its antiviral, antifungal, antimicrobial, insecticidal, hepatoprotective and The research, published in the Antiviral Research journal by experts at different institutions and companies in Beijing, identified four herbal extracts, including artemisia, that could be considered as candidates for the development of drugs for treatment of SARS. 16 This helps to kill viruses as well as inhibiting replication of already infected cells. ArtemiLife Inc., a US based company, is providing the necessary plant material for the studies. Artemisia afra, the African wormwood, [4] is a common species of the genus Artemisia in Africa, with a wide distribution from South Africa, to areas reaching to the North and East, as far north as Ethiopia.
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